The Program to Build Leadership and Accountability in Nigeria’s Health System (PLAN-Health) is a five-year, President’s Emergency Fund for AIDS Relief (PEPFAR) associate award through the United States Agency for International Development (USAID). It has been implemented by Management Sciences for Health in Gombe and Akwa Ibom States and the Federal Capital Territory, Abuja. From commencement in 2010, the project aimed to strengthen the leadership and management capacities of 30 public sector health institutions and civil society organizations for improved delivery of quality HIV and AIDS and other health services in Nigeria. PLAN-Health is assisting civil society organizations and public sector health institutions to become more adept at developing and maintaining the health services needed to meet health challenge targets by 2015. Through workshops, internships, embedded consultancies, technical assistance, coaching, and the PEPFAR Health Professionals Fellowship, PLAN-Health has helped to build strong and viable organizations by developing leadership skills and more capable managers. It has created mechanisms for efficient, coordinated systems and processes, and is promoting a continuous increase in institutional commitment to change and ownership.